Figure 2.

Biosynthetic Pathways of Protectins and Maresins in Macrophages and MaR-2 in Brown Adipose Tissue Activation. Right Side: The biosynthetic pathway of both Protectins and Maresins as derived in macrophages. Lower Left Corner: In obesity, thermogenesis activates brown adipose tissue (BAT) via cold-induced stimulation of β3-adrenergic receptors and triggers the upregulation of ALOX12 (12-lipoxygenase) and soluble epoxide hydrolase enzymes, leading to the biosynthesis of MaR-2. Bottom Right: In the liver, MaR2 significantly increases levels of both infiltrating CD45⁺CCR2^-Ly6C^lo monocytes, triggering receptors expressed on myeloid cells-2 (TREM2)⁺ Kupffer cells [88].