Table 4.
Clinical significance of identified HBV mutations.
| Mutation | Genotype | Clinical Significance |
|---|---|---|
| rtH100M | E | Not characterized |
| rtI103V | A | Not characterized |
| rtV103I | D | Not characterized |
| rtS105T | A | Not characterized |
| rtS109P | A, E | Not characterized |
| rtR110G | A | Not characterized |
| rtL115V | D | Not characterized |
| rtN122H | A | Not characterized |
| rtF122L | D | Not characterized |
| rtN124H | A | Not characterized |
| rtM129L | A | Not characterized |
| rtQ130P | D | Not characterized |
| rtN131D | A | Not characterized |
| rtL132M | E | Not characterized |
| rtY135S | D | Partly linked to drug resistance |
| rtW153R | A | Not characterized |
| rtV163I | A | Not characterized |
| rtL164M | D | Not characterized |
| rtS213T | D | Not characterized |
| rtG210R | D | Not characterized |
| rtV214E | D | Not characterized |
| sI92C | E | Not characterized |
| sY100S | D | Impair production and secretion of HBsAg, associated with OBI [25,26,27] |
| sK122R | A | Immune escape, Associated with OBI [28,29,30] |
| sT127P | D | Immune escape [31,32] |
| sS140L | E | Immune escape [33] |
| sE164G | D | Not characterized |
| sP188L | E | Not characterized |
| sS193L | A | Not characterized |
| sA194V | A | Not characterized |
| sI195T | A | Not characterized |
| sM197T | A | Correlate with low HBV viral load [34] |
| sW201 * | D | Reduces intracellular HBsAg [35] |
| sP203R | A | Associated with HCC [36] |
| sS204R | D | Reduces HBsAg secretion [37] |
| sS204N | A | Correlate with low HBV viral load [34] |
| sY206N | D | Not characterized |
| sS207N | A | Immune escape [38,39,40] |
Abbreviation: rt: reverse transcriptase, s: surface. Bold = novel, *: stop codon.