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. 2024 Jun 15;12(6):1206. doi: 10.3390/microorganisms12061206

Table 1.

Guidelines for classification of CDI [12,53].

Severity Symptoms and Laboratory Evidence
Mild to moderate

  • Stool frequency of three to five per day

  • WBC ≤ 15,000 cells/mm3

  • Serum creatinine level < 1.5 times of baseline
Severe

  • Abdominal tenderness

  • Severe colitis (with evidence of clinical examination)

  • WBC ≥ 15,000 cells/mm3

  • Acute rising serum creatinine level > 1.5 times of baseline
Severe and fulminant

  • Hypotension, ileus, or toxic megacolon

  • Fever (temperature ≥ 38.5 °C)

  • WBC ≥ 35,000 cells/mm3

  • Organ failure
Recurrence

  • Relapse of CDI within 8 weeks of completion of treatment