TABLE 1.
Gag-specific CTL responses in Boston cohorts studied
| Best-recognized peptide | Subject | HLA class I type | Racial group | CTL (per one million PBMCs) | Defined dominant epitope [HLA restriction]a |
|---|---|---|---|---|---|
| p17.2A | 014-TCH | A*0201/3 B35/44 Cw1/4 | African American Caucasoid | 600 | RLRPGGKKK [A3] |
| 019-TCH | A3/*3001 B51/60 CW15/16 | Caucasoid | 723 | KIRLRPGGK [A3] | |
| 027-TCH | A1/*0201 B18/57 Cw6/7 | Caucasoid | 472 | WEKIRLRPGGKKKYK [NDb] | |
| 048-TCH | A1/*0201 B27/37 Cw2/6 | Caucasoid | 780 | IRLRPGGKK [B27] | |
| 049-TCH | A1/24 B27/37 Cw1/6 | Caucasoid | 170 | IRLRPGGKK [B27] | |
| 004-BMC | A3/*3001 B7/35 Cw4/7 | Haitian | 273 | KIRLRPGGK [A3] | |
| 011-BMC | A24/29 B7/45 Cw6/7 | African American | 170 | RLRPGGKKKYK [ND] | |
| 96/00600 | A3/11 B44/62 Cw3/5 | Caucasoid | 225 | WEKIRLRPGGKKKYK [ND] | |
| 96/01114 | A2/3 B35/- Cw4/- | Caucasoid | >1,000 | RLRPGGKKK [A3] | |
| 85/00003 | A*0201/3 B7/51 Cw7/- | Caucasoid | >1,000 | RLRPGGKKK [A3] | |
| JC | A*0201/3 B35/55 Cw-/- | Caucasoid | 880 | RLRPGGKKK [A3] | |
| GV | A*0201/3 B8/62 Cw7/10 | Caucasoid | 280 | RLRPGGKKK [A3] | |
| TD | A3/68 B35/44 Cw4/7 | Caucasoid | 1,280 | RLRPGGKKK [A3] | |
| p17.4A | 042-TCH | A3/33 B35/53 Cw4/- | African American | >1,000 | WASRELERF [ND] |
| p17.8 | 001-UNC | A*0201/74 B7/35 Cw7/16 | African American | 2,800 | SLYNTVATL [A*0201] |
| 004-TCH | A*0202/29 B7/44 Cw7/16 | Caucasoid Hispanic | 1,400 | SLYNTVATL [A*0202] | |
| 032-TCH | A*0201/23 B44/61 Cw2/4 | Caucasoid | 160 | SLYNTVATL [A*0201] | |
| 034-TCH | A*0201/68 B35/44 Cw4/7 | Caucasoid | 120 | SLYNTVATL [A*0201] | |
| 036-TCH | A*0201/68 B18/51 Cw5/16 | Haitian | 213 | SLYNTVATL [A*0201] | |
| 040-TCH | A*0201/34 B7/52 Cw7/16 | Haitian | 400 | SLYNTVATL [A*0201] | |
| 007-BMC | A*0201/23 B14/45 Cw6/8 | African American | 520 | SLYNTVATL [A*0201] | |
| 010-161j | A*0201/3 B7/60 Cw3/7 | Caucasoid | >2,000 | SLYNTVATL [A*0201] | |
| 9354 | A*0201/3 B7/35 Cw4/7 | Caucasoid | 5,600 | SLYNTVATL [A*0201] | |
| 013-661 | A1/*0201 B44/52 Cw-/- | Caucasoid | 920 | SLYNTVATL [A*0201] | |
| 85/00003 | A*0201/3 B7/51 Cw7/- | Caucasoid | >1,000 | SLYNTVATL [A*0201] | |
| p17.8A | 013-199 | A*0201/*3002 B44/51 Cw-/- | Caucasoid | 5,650 | RSLYNTVATLY [A*3002] |
| p17.9A | 028-BMC | A1/*0201 B8/63 Cw7/- | Caucasoid | >1,000 | DVKDTKEAL [ND] |
| 045-TCH | A23/68 B45/72 Cw2/16 | Haitian | 133 | RIDVKDTKEAL [ND] | |
| p24.2 | 033-BMC | A34/68 B57/71 Cw3/7 | Haitian | 500 | VQHAISPRTLNAWV [ND] |
| p24.3 | GS | A*0201/30 B44/57 Cw-/- | Caucasoid | 770 | KAFSPEVIPMF [B57] |
| p24.5 | 015-TCH | A*3002/68 B14/*5802 Cw6/8 | African American | 462 | GATPQDLNTMLNTV [ND] |
| 016-TCH | A*3001/- B42/- Cw17/- | African American | 507 | TPQDLNTML [B42] | |
| 044-TCH | A*0201/30 B42/52 Cw16/17 | African American | 1,450 | TPQDLNTML [B42] | |
| 009-BMC | A*0201/*3002 B14/27 Cw1/8 | African American | 360 | TPQDLNTML [B14/Cw8] | |
| 021-BMC | A3/*3001 B42/- Cw17/- | African American | >1,000 | TPQDLNTML [B42] | |
| 026-BMC | A3/- B42/*5703 Cw7/17 | Hispanic | 2,460 | TPQDLNTML [B42] | |
| 032-BMC | A1/80 B42/45 Cw16/17 | African American | 1,810 | TPQDLNTML [B42] | |
| 94/00181 | A11/24 B14/44 Cw8/16 | Caucasoid | >1,000 | TPQDLNTML [ND] | |
| p24.13 | 029-TCH | A*0201/32 B7/8 Cw7/15 | Caucasoid | 433 | EIYKRWII [B8] |
| p24.14 | 023-TCH | A23/26 B62/72 Cw2/3 | African American | 660 | GLNKIVRMY [B62] |
| 043-TCH | ND | African American | 1,500 | KRWILGLNKIVRMY [ND] | |
| p24.17 | KM | A3/- B14/60 Cw3/8 | Caucasoid | 1,600 | DRFYKTLRA [B14] |
| JFM | A*0201/68 B14/44 Cw5/8 | Caucasoid | 120 | DRFYKTLRA [B14] | |
| p24.22 | KS | A3/- B7/- Cw7/- | Caucasoid | 1,020 | GPSHKARVL [B7] |
| DK | A*0201/11 B18/44 Cw-/- | Caucasoid | 1,300 | ACQGVGGPGHK [A11] |
a
In each case the defined epitopes shown represent the HLA restriction, and epitope optimization was determined for each subject. Optimized epitopes described elsewhere (for example, WASRELERF as a B35-restricted epitope [10]) are not shown unless the response was demonstrated in the subjects studied.
b
ND, not determined.