Table 1.
Baseline Demographic and Clinical Characteristics for Responders vs Nonresponders Based on Change in PANSS Total Score (≥20% Change from Baseline at Week 4)
| Baseline Characteristic | PANSS Response at Week 4 (N = 143a) | Effect Sizeb for Responders vs Nonresponders | |
|---|---|---|---|
| Responders (n = 67) |
Nonresponders (n = 76) |
||
| Age, y, mean (SD) | 42.3 (9.61) | 43.0 (10.72) | 0.07 |
| Sex, male, n (%) | 48 (71.64) | 60 (78.95) | 1.48 (0.69, 3.19) |
| PANSS total score, mean (SD) | 94.7 (7.86) | 94.3 (8.68) | 0.05 |
| PANSS Positive score, mean (SD) | 26.3 (3.08) | 25.0 (3.35) | 0.40 |
| PANSS Negative score, mean (SD) | 22.4 (3.42) | 23.3 (3.89) | 0.24 |
| PANSS General Psychopathology score, mean (SD) | 46.0 (5.56) | 46.0 (4.94) | 0.01 |
| CGI-S, mean (SD) | 4.9 (0.66) | 4.8 (0.61) | 0.13 |
| SAS score, mean (SD) | 0.2 (0.57) | 0.2 (0.97) | 0.03 |
| BARS total score, mean (SD) | 0.04 (0.21) | 0 | 0.32 |
| AIMS total score, mean (SD) | 0.01 (0.12) | 0.36 (1.40) | 0.33 |
| AIMS total score > 0, n (%) | 1 (1.49) | 9 (11.84) | 8.87 (1.09, 71.95) |
| Patients not on antipsychotic medications within 30 days prior to first dose of study drug, n (%) | 21 (31.34) | 20 (26.32) | 1.28 (0.62, 2.64) |
| Patients on anticholinergic medications within 30 days prior to first dose of study drug, n (%) | 3 (4.48) | 6 (7.89) | 1.83 (0.44, 7.62) |
aMissing handwriting data at baseline (n = 33) were mainly due to issues with handwriting test procedures.
bEffect size, a measure of the difference in the baseline characteristic for responders vs nonresponders, was calculated as Cohen’s d for continuous characteristics and odds ratios (95% CIs) for dichotomous characteristics.
AIMS, Abnormal Involuntary Movement Scale; BARS, Barnes Akathisia Rating Scale; CGI-S, Clinical Global Impressions-Severity scale; PANSS, Positive and Negative Syndrome Scale; SAS, Simpson-Angus Scale.