Table 2.

Mean (SE) Baseline Handwriting Kinematics Scores for Responders vs Nonresponders at Week 4

	Responders	Nonresponders	Effect Size (Cohen’s d)
Peak velocity, mean (SE), cm/s
PANSS response,a n	67	76b
Complex loops	8.8 (0.53)	12.1 (0.84)	0.55
Maximum speed circle drawing	18.0 (0.87)	23.7 (1.44)	0.56
Overlay circles	12.6 (0.64)	17.2 (1.24)	0.54
Left-right loops	11.2 (0.65)	14.6 (1.33)	0.39
CGI-S response,c n	41	102d
Complex loops	9.0 (0.62)	11.2 (0.69)	0.36
Maximum speed circle drawing	18.0 (1.00)	22.3 (1.17)	0.41
Overlay circles	12.3 (0.71)	16.2 (0.99)	0.45
Left-right loops	10.9 (0.72)	13.9 (1.04)	0.33
%NBM, mean (SE)
PANSS response,a n	67	76b
Complex loops	57.1 (2.82)	47.4 (3.28)	0.38
Maximum speed circle drawing	9.2 (1.52)	9.1 (1.53)	0.01
Overlay circles	30.6 (3.01)	24.3 (3.12)	0.24
Left-right loops	58.7 (3.50)	47.0 (3.59)	0.40
CGI-S response,c n	41	102d
Complex loops	59.6 (3.67)	48.9 (2.69)	0.41
Maximum speed circle drawing	9.2 (2.12)	9.2 (1.25)	<0.01
Overlay circles	32.9 (3.85)	25.0 (2.63)	0.31
Left-right loops	63.4 (4.50)	48.1 (2.99)	0.52

^aPANSS response defined as ≥20% reduction from baseline in PANSS total score.

^bFor PANSS nonresponders, n = 75 for complex loops and left-right loops tasks.

^cCGI-S response defined as ≥2-point improvement from baseline in CGI-S score.

^dFor CGI-S nonresponders, n = 101 for complex loops and left-right loops tasks.

%NBM, percentage of nonballistic movements; CGI-S, Clinical Global Impression-Severity Scale; PANSS, Positive and Negative Syndrome Scale.