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General architecture of potassium channels. (A) Inwardly rectifying two transmembrane helices channel 2TM/P. (B) Voltage-gated and ligand-gated six transmembrane helices channel (6TM/P, plus signs on S4 represent its role in voltage sensing). (C) Eight transmembrane helices/two-pore hybrid channel (8TM/2P). (D) Tandem pore domain channel (4TM/2P). Created with BioRender.com, accessed on 4 May 2024.
