Fig. 3. Connector hubs encompass key ascending neuromodulatory nuclei.
(A) Network schematic illustrating a graph-based definition of communities and connector hubs. (B) Structural communities anatomically recapitulate functional (rsfMRI) networks of the mouse brain. Structural communities (SC; top row; see Materials and Methods) were matched to corresponding functional communities [FC; bottom row; Liska et al. (19)]. (C) Neuromodulatory nuclei are configured as connector hubs. Global (left), out-connector (middle), and in-connector (right) hubs were computed on the basis of the participation coefficient metric, accounting for outgoing or incoming connections only. ACA, anterior cingulate area; Acb, nucleus accumbens; AI, agranular insular area; Amy, amygdala; CS, superior central nucleus raphe; DRN, dorsal nucleus raphe; ENT, entorhinal area; HP, hippocampus; Ha, habenula; Hy, hypothalamus; LC, locus coeruleus; LHb, lateral habenula; MD, mediodorsal nucleus of the thalamus; MOp, primary motor areas; MOs, secondary motor area; OLF, olfactory areas; ORB, orbital areas; PG, pontine gray; PIR, piriform area; RE, nucleus reuniens; RSP, retrosplenial area; SEP, septal complex; STRd, striatum dorsal region; STRv, striatum ventral region; TEa, temporal association areas; vHP, ventral hippocampal area; VIS, visual areas; VTA, ventral tegmental area; ZI, zona incerta.