Figure 3.

Oral administration of Pediococcus pentosaceus MIANGUAN2 can downregulate multiple inflammatory signaling pathways in the lung. (A−C) GSEA analysis showed the inhibition of TNF (A), apoptosis (B), and NF-Kappa B signaling pathways (C) in the lung tissues of the MIANGUAN2 group compared with the virus group. The clustering heatmaps on the right display the gene expression profiles with dominant roles in the three inflammation pathways, respectively. GSEA: gene set enrichment analysis, NES: normalized enrichment score, FDR-q: false discovery rate q value.