Table 6.

The effect of CE treatment of male rats on the postnatal offspring development.

Parameters			Experimental Groups a
			♂  ×  ♀	♂  ×  ♀	♂  ×  ♀	♂  ×  ♀
			H2O × Intact	CE, 100 mg/kg × Intact	CE, 500 mg/kg × Intact	CE, 1000 mg/kg × Intact
Number of litters evaluated			7	7	7	7
Number of newborn pups in the litter b			8.4 ± 0.4	8.1 ± 0.7 ns	8.5± 0.3 ns	9.3 ± 0.8 ns
Number of surviving pups per female rat post-delivery	Day 7	Number b	8.1 ± 0.6	8.1 ± 0.7 ns	8.5± 0.3 ns	9.3 ± 0.8 ns
		%	96.4	100	100	100
	Day 14	Number b	8.1 ± 0.6	7.9 ± 0.6 ns	8.5± 0.3 ns	9.3 ± 0.8 ns
		%	96.4	97.5	100	100
	Day 21	Number b	7.9 ± 0.6	7.7 ± 0.6 ns	8.3 ± 0.4 ns	9.3 ± 0.8 ns
		%	94.0	95.1	98.0	100
Pups weight (g) b	Day 1		6.2 ± 0.2	6.3 ± 0.3 ns	6.1± 0.4 ns	6.0 ± 0.2 ns
	Day 4		9.1 ± 0.5	9.0 ± 0.5 ns	8.9 ± 0.7 ns	8.9 ± 0.3 ns
	Day 7		12.3 ± 0.8	12.7 ± 1.1 ns	11.9 ± 0.5 ns	11.8 ± 0.6 ns
	Day 14		22.6 ± 0.9	22.9 ± 0.9 ns	20.9 ±1.5 ns	20.9 ± 1.3 ns
	Day 21		32.4 ± 2.2	33.2± 2.0 ns	32.2 ± 3.4 ns	31.2 ± 3.0 ns

^a—male rats were orally treated with either H₂O (control) or CE (100, 500, or 1000 mg/kg bw/day) for 60 days before mating; ^b—mean ± SE. ^ns—the differences between the CE-treated and control groups were not statistically significant.