Figure 3.

Histoarchitecture of rat paw tissue at 3 h of carrageenan injection (hematoxylin and eosin stain) (original magnification = 100× and scale bar = 50 μm): (a) control, showing normal architecture of dermis and hypodermis; (b) carrageenan, characterized by acute inflammation in the dermis and hypodermis extending to the underlying muscular tissue with a large influx of inflammatory cells; (c) carrageenan + curcumin; (d) carrageenan + demethoxycurcumin; and (e) carrageenan + bisdemethoxycurcumin showed a moderate density of inflammatory cells. The number of arrows shows the relative density of penetrated inflammatory cells.