Table 1.

Common chemical properties of resveratrol and quercetin that contribute towards the pharmacological mechanisms targeting colon cancer.

Description	Resveratrol		Quercetin
Chemical Properties [57,58]
Solubility	PEG-400 (373 mg/mL), Ethanol (88 mg/mL), Labrasol (14 mg/mL), Tween 80 (7 mg/mL), Cremophore EL (6.7 mg/mL), Polysorbate 80 (5 mg/mL), water (0.05 mg/mL)		DMSO (67 mg/mL), Ethanol (21 mg/mL), Acetone (80 mmol/L), t-amyl alcohol (67 mmol/L), Acetonitrile (5.4 mmol/L), water (0.4 mg/L)
Stability	Unstable at high temperatures and at alkaline pH		Unstable at higher temperatures and at alkaline pH
Pharmacological Targets in CRC [23,24,25,26,27,28,29,30,31,32,33,34,35,51,52,53,54,55,56]
Pathways/Molecules	Upregulated	Downregulated	Upregulated	Downregulated
Anti-cancer	SIRT1, p38-MAPK, PDH,	MMP-9, VEGF, EMT, HIF-1alpha, TSP1, NO, MMP-2, iNOS, AKT/mTOR, Wnt,	P53, BAX, caspase-3, and caspase-9,	Wnt/β-catenin, PI3K/AKT, p-STAT3, NF-κB,