Table 1. Change in highly related cluster frequencies between 2016–2017 and 2020–2021.

Study Period	2016–2017			2020–2021
Highly related cluster	IBD	Number of samples	Frequency in 2016–2017 (%)	IBD	Number of samples	Frequency in 2021–2021 (%)
1	0.867	88	11.8	0.957	2	0.4
2	0.627	97	13.0	0.545	38	7.2
3	0.708	25	3.4	0.534	107	20.2
4	0.886	5	0.7	0.722	63	11.9
5	0.763	64	8.6	-	0	0.0
6	0.966	23	3.1	0.841	37	7.0
7	0.476	124	16.7	0.409	49	9.3
8	0.614	54	7.3	0.547	13	2.5
9	0.578	3	0.4	0.566	39	7.4
10	0.512	18	2.4	0.424	2	0.4
11	0.485	8	1.1	0.541	32	6.0
12	0.405	59	7.9	0.997	2	0.4
13	0.525	51	6.9	0.421	37	7.0
Other	0.292	125	16.8	0.299	108	20.4
Total	0.294	744	100.0	0.308	529	100.0