Body weight, food consumption, and endocrine changes in 12 weeks of allulose consumption. Throughout the 12 wk trial, rats manifested several significant changes. Firstly, allulose consumption blunted weight gain with a Western diet ((A); n = 10), reflected in a reduced overall food consumption ((B); n = 10). Insulin (C) and glucose (D) levels, used to compute the HOMA-IR (E), while increased significantly in the WD+stevia group, were normal in the WD+allulose group (n = 8). GLP-1 was significantly elevated throughout the trial in both groups consuming allulose ((F); n = 8). * p < 0.05; ** p < 0.005; *** p < 0.0005.