. Author manuscript; available in PMC: 2024 Jun 26.

Published in final edited form as: Clin Gastroenterol Hepatol. 2022 Dec 20;21(3):581–603.e33. doi: 10.1016/j.cgh.2022.12.006

Table 6.

Guideline Differences Between Early-Onset Colorectal Cancer (eoCRC) and CRC Diagnosed After the Age of 50 Years

	CRC before age 50	CRC after age 50

Genetics	Germline multigene panel testing always recommended	Germline multigene panel testing recommended under specific circumstances (tumor and clinical features suggestive of hereditary cancer syndromes)
Family history	Family history: mandatory	Family history: recommended
Surgery	No difference yet
Chemotherapy	No difference yet
Targeted therapy	No difference yet
Fertility	All patients should receive information on fertility preservation options	Most patients are not candidates for fertility preservation
Sexuality	No difference yet
Nausea and vomiting	Consider enhanced antiemetic prophylaxis	Regular antiemetic prophylaxis
Endoscopic management	No difference yet
Post-treatment follow-up	Should not be discharged from follow-up	Follow country-specific guidelines for post-treatment surveillance