Figure 4.
Liposomes containing cholesterol cross the BBB model more than liposomes containing PEG. Fluorescence of DiIC18 was barely detected in the BBB model within 3 h after adding liposomes to the blood side; however, liposomes with cholesterol (Cho-lip, n = 4) tended to pass through the BBB more than liposomes with PEG (PEG-lip, n = 4) at 24 h (p = 0.082) and showed significantly higher permeability at 48 h compared with PEG-lip (p = 0.0067). Values are presented as the mean ± standard error.