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. 2024 Jun 4;16(6):762. doi: 10.3390/pharmaceutics16060762

Figure 6.

Figure 6

Several types of PC and PE incorporated into liposomes led to altered spontaneous activity in the OF test. (A) The radius of the smallest circle was one-third that of the largest circle (r), and the radius of the medium-sized circle was two-thirds that of the largest circle. The white and yellow areas show the central region, and the peripheral region is indicated as the red area. (B–D) Total distance traveled. (E,G,I) Time spent in the central region. (F,H,J) Time spent in the peripheral region. (K–M) Distance traveled in the central region. (N–P) Distance traveled in the peripheral region. (Q) The OF was divided into 25 areas to count the crossings. The yellow region was divided into eight equal areas, and the red region was divided into 16 equal areas. (R–T) Number of area crossings. Values are presented as the mean ± standard error. The rat numbers in each group were as follows: (B,E,F,K,N,R) Egg PC (n = 9), PE(18:0/18:0) (n = 10), PE(18:0/22:6) (n = 9), PE(18:0/20:4) (n = 10), and PE(P-18:0/20:4) (n = 7). (C,G,H,L,O,S) Egg PC (n = 10), PC(16:0/22:6) (n = 10), PC(O-16:0/22:6) (n = 6), PC(O-18:0/22:6) (n = 10), and PE(O-16:0/22:6) (n = 3). (D,I,J,M,P,T) Egg PC (n = 9), PC(18:0/20:0) (n = 10), PC(18:0/20:4) (n = 10), PC(O-18:0/20:4) (n = 9), and PC(P-18:0/20:4) (n = 6). Differences were evaluated using Hsu’s MCB test.