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. 2024 Jun 4;16(6):762. doi: 10.3390/pharmaceutics16060762

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The impact of phospholipid moiety substitutions on behaviors. (A) DHA at sn-2 and an ether linkage at sn-1 in PE may control exploratory behaviors. (B) A vinyl–ether linkage at sn-1 in PC with 20:4, and palmitic acid at sn-1 and the substitution of choline with ethanolamine at sn-3 in PC with 22:6, may reduce anxiety-like behaviors. (C) Palmitic acid at sn-1 and stearic acid and DHA at sn-2 may reduce sociability. By contrast, alkyl–ether linkage and stearic acid at sn-1 may combine to enhance social interaction with a familiar rat.