Figure 6.

The effect of treatment with trehalose (2% or 4% solution daily (“Aβ + 2% T” or “Aβ + 4% T”) or 4% solution every other day (“Aβ + 4% T/2”), 14 days) on the behavior in the open field test in mice with Aβ-induced AD-like pathology. To set up the AD model, mice were given bilateral i.c.v. injections of Aβ25–35. The control group received vehicle (sterile water) i.c.v. injections. The treatment with trehalose was started 2 days after the i.c.v. Aβ25–35 administration. (A) distance traveled (cm), an index of locomotor activity; (B) a number of rearing bouts, an index of vertical locomotor activity and exploratory activity; (C) time spent in the center (s), an index of anxiety. The data are expressed as the median and interquartile range (Q1; Q3) of the values obtained in an independent group of animals (n = 6 to 9 per group). Statistically significant differences: * p < 0.05 vs. control group; ^ p < 0.05, ^^ p < 0.01 vs. “Aβ + 4% T” group.