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Effect of mutation Q573K in RNA-dependent RNA polymerase on the interaction with a Template-Primer RNA. (a) In the wild-type RNA-dependent RNA polymerase, Q573 is too far from the template to interact with it (ΔG = 0 kJ.mol−1). (b) In the case of Q573K, the cationic group of lysine interacts strongly with the template (ΔG = – 26. 5 kJ.mol−1), which may result in an inactive enzyme-substrate complex.
