Fig. 4.

Comparing brain images and derived results for AMP SCZ vs KePROS protocol. (A) Panels (i)–(vi) illustrate the strong similarity of structural-derived results from a 51-year-old healthy male scanned on the Prisma at Washington University using the AMP SCZ protocol (top row), compared to that same individual scanned on the Verio at The Nairobi Hospital using the KePROS structural protocol (bottom row). (i) Axial slice of T1w scan, (ii) T2w scan, and (iii) FreeSurfer’s “wmparc” volumetric segmentation, each with the FreeSurfer “pial” (blue) and “white” (green) surface contours overlaid; (iv) Freesurfer’s “aparc.a2009s” surface segmentation displayed on “very inflated” left hemisphere lateral and medial surfaces; (v) smoothed T1w/T2w ratio (“myelin”) map (“SmoothedMyelinMap_BC”); (vi) mid-thickness surface. Results were generated using the HCPpipelines.⁹¹ While there is a noticeable difference in image SNR for the same 0.8 mm isotropic spatial resolution (due to the 16-ch, rather than 32-ch, coil), the quality of the KePROS structural acquisition is sufficient for accurate surface generation and yields highly similar segmentations and myelin maps. (B) Results from 2 different individuals of resting-state functional connectivity network maps generated using network template matching,⁹² with a small amount (6 mm full-width-half-maximum) of surface-based spatial smoothing applied to the input data. The AMP SCZ fMRI scans were acquired from a 20-year-old female healthy control participant on a Skyra scanner using the AMP SCZ fMRI protocol (ie, 20 total minutes with 2.4 mm voxels and MB factor of 6). The KePROS fMRI scans were acquired from a 24-year-old male CHR participant using the KePROS fMRI protocol (ie, 30 total minutes with 3 mm voxels and MB factor of 3). Note that the KePROS and AMP SCZ examples shown have comparable overall quality of their individually derived connectivity network maps. (C) Results from the same 2 individuals shown in (B) of TRACULA analyses of white matter tracts⁹³ generated from the diffusion-weighted scans of the respective protocols (top: left view; bottom: inferior view). AMP SCZ “Tier 2” (Skyra) diffusion protocol was acquired over 10 min with 1.8 mm isotropic voxels, MB factor of 3, and 126 diffusion directions (4 shells with b = 200, 500, 1000, and 2000 s/mm²). KePROS was acquired over 12 min with 2 mm isotropic voxels, MB factor of 2, and the same diffusion directions and b-values. The TRACULA results are of comparable quality. See table 4 for further protocol details. AMP SCZ, Accelerated Medicine Partnership Schizophrenia; CHR, clinical high risk for psychosis; KePROS, Kenya Psychosis-Risk Outcomes Study.