Table 3.
Demethylation of 5mCpG in promoter regions of NAFLD signaling pathway
| Gene Name | DMR Location in Promoter Region |
DMR (Methylation %) |
|||||
|---|---|---|---|---|---|---|---|
| Chromosome | Start | End | 3 h | 6 h | 12 h | 24 h | |
| ADRA1A | chr8 | 26,722,718 | 26,723,338 | −30.28 | −41.25 | −30.57 | −30.81 |
| COX7B | chrX | 77,154,454 | 77,154,461 | −30.90 | −83.31 | 0.00 | 0.00 |
| COX8A | chr11 | 63,740,862 | 63,741,002 | −25.87 | −35.30 | 0.00 | −34.15 |
| LEP | chr7 | 127,880,823 | 127,880,836 | 0.00 | −35.18 | −62.70 | 0.00 |
| PPARG | chr3 | 12,352,022 | 12,393,324 | 0.00 | −37.32 | −27.41 | −27.57 |
| SDHA | chr5 | 217,194 | 217,240 | 0.00 | −37.82 | 0.00 | −23.50 |
| SDHB | chr1 | 17,381,359 | 17,381,392 | 0.00 | −39.54 | −38.35 | 0.00 |
| UQCRC1 | chr3 | 48,647,954 | 48,648,002 | −23.76 | −56.12 | −23.36 | −26.32 |
Gene name represent the official gene symbol as recorded in NCBI database. Differentially methylated region (DMR) (methylation %) represents the percentage change in methylation levels induced by cholestenoic acid (CA) treatment at various time points compared with the control group. P = at 6 h. NAFLD, nonalcoholic fatty liver disease.