TABLE 2.
Univariate and multivariate Cox hazards analyses examining factors associated with time to LMD diagnosis
| Factor | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p Value | OR (95% CI) | p Value | |
| Age | 1.33 (0.39–4.80) | 0.65 | ||
| M, vs F | 0.77 (0.40–1.46) | 0.42 | ||
| Minority, vs White non-Hispanic | 2.17 (1.21–3.88) | 0.01 | 1.73 (0.91–3.27) | 0.09 |
| Cancer type, breast/gynecological/urothelial vs other | 2.36 (1.33–4.18) | 0.003 | 1.17 (0.60–2.25) | 0.65 |
| Tumor side, rt vs lt | 1.20 (0.66–2.16) | 0.55 | ||
| Location, cerebellum/insula/occipital vs other | 3.07 (1.72–5.50) | 0.0002 | 3.25 (1.73–6.11) | 0.0003 |
| Absence of extracranial disease | 1.94 (1.07–3.54) | 0.03 | 2.49 (1.27–4.88) | 0.008 |
| Tumor volume | 2.61 (0.46–11.93) | 0.24 | ||
| Time from BM diagnosis to surgery | 0.96 (0.14–3.75) | 0.96 | ||
| No. of total BMs at surgery | 0.94 (0.12–4.70) | 0.95 | ||
| No. of BMs resected at surgery, 2 vs 1 | 1.95 (0.60–6.29) | 0.27 | ||
| Additional craniotomies | 0.99 (0.52–1.92) | 0.99 | ||
| BM hemorrhage | 0.73 (0.39–1.35) | 0.32 | ||
| Cystic tumor | 0.93 (0.47–1.84) | 0.84 | ||
| Contact w/ cortical surface | 1.32 (0.70–2.51) | 0.39 | ||
| Contact w/ ventricle | 2.82 (1.53–5.19) | 0.0009 | 2.82 (1.50–5.30) | 0.001 |
| GTR vs STR | 0.89 (0.45–1.76) | 0.74 | ||
| Prior intracranial RT | 1.12 (0.50–2.49) | 0.79 | ||
| Immediate postop focal RT vs WBRT | 1.13 (0.48–2.67) | 0.78 | ||
| WBRT prior to LMD diagnosis | 1.06 (0.54–2.08) | 0.87 | ||
| CPI Tx before surgery | 1.34 (0.48–3.76) | 0.58 | ||
| CPI Tx after surgery | 0.71 (0.34–1.46) | 0.35 | ||
| Other targeted Tx before surgery | 1.32 (0.72–2.45) | 0.37 | ||
| Other targeted Tx after surgery | 1.32 (0.74–2.35) | 0.35 | ||
| Any systemic therapy postop | 0.68 (0.36–1.29) | 0.24 | ||
Boldface type indicates statistical significance.