FIGURE 9.

Schematic summary of the FAK‐mediated adipose tissue inflammation and pancreatic β cell apoptosis in diabetes. FAK deficiency in adipocytes activates the TRAF6/TAK1/NF‐κB signalling pathway as well as the activation of caspase3, which leads to inflammatory response as well as apoptosis in adipocytes, producing TNF‐α, IL‐1β and MCP1 inflammatory factors. These inflammatory factors further stimulate macrophages to polarise to M1 type, producing large amounts of inflammatory factors that circulate through the body and stimulate pancreatic β cell apoptosis, exacerbating the pathogenesis of diabetes.