FIGURE 12.

Schematic diagram illustrating the regulatory mechanism of scutellarin in microglia‐mediated neuroinflammation and apoptosis in IS. Scutellarin inhibited the NF‐κB pathway, pro‐apoptotic proteins Bax and caspase‐3, and inflammatory factors TNF‐α and IL‐1β in microglia after IS. It also promoted the activation of the PI3K/AKT/GSK3β pathway and anti‐apoptotic protein Bcl‐2. Conversely, the PI3K pathway inhibitor promoted the expression of the NF‐κB pathway, pro‐apoptotic proteins, and inflammatory factors while inhibiting the expression of the PI3K/AKT/GSK3β pathway and anti‐apoptotic protein Bcl‐2. These results suggest that scutellarin regulates activated microglia‐mediated neuroinflammation and apoptosis via the PI3K/AKT/GSK3β and NF‐κB pathways.