Extended Data Fig. 10. TrkB^cKO females display deficits in mating behaviours.

a, Ethograms of mating behaviours of hormone-primed TrkB^cKO (n = 9) and littermate control (n = 11) females within a 75 min testing period across two trials, with each trial two weeks apart. b-e, Quantifications of mount start time (b), intromission quotient (total intromission time/(total intromission time + total mount time)) (c), intromission start time (d), and average intromission duration per bout (e), within each trial. Unpaired t-test, p > 0.05. f, Comparison of intromission quotient of wild-type females in dioestrus (without hormone priming) and with hormone priming. g, Ethograms of mating behaviour of naturally-cycled TrkB^cKO (n = 8) and littermate control (n = 10) females. Females were separated from males 10 min after the start of intromission to avoid pregnancy. If no intromission occurred, the session was stopped at 30 min. h-n, Quantifications of the fraction of time that a male mouse spends sniffing the female mouse before mounting (h), mounting start time (i), mount duration for each bout (j), intromission start time (k), intromission duration for each bout (l), and the number of darting (m) and combative behaviours (n) during mating for naturally-cycled TrkB^cKO (n = 8) and littermate control (n = 10) females. Unpaired t-test, * p < 0.05, ** p < 0.01. Error bars, s.d.

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