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. 2024 Jun 26;630(8018):994–1002. doi: 10.1038/s41586-024-07570-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — Comparison of the synaptic complex structures, DNA recognition mechanisms, and DNA recombination mechanisms between IS621 and Cre (PDB: 1CRX and 3CRX). In the recombination reactions catalysed by IS621 and Cre, the top strands in two DNA molecules are cleaved, forming covalent protein–DNA intermediates. DNA cleavage sites are indicated by yellow triangles. Note that the relative angles between the two DNA molecules differ by ~180° between the synaptic complexes of IS621 and Cre, resulting in the opposite orientations of their HJ intermediates (parallel for IS621 and antiparallel for Cre). The orientations of the two DNA molecules are indicated by arrows. TS, top strand; BS, bottom strand.