Table 3.
Median overall survival (OS) for the four breast cancer subgroups across the different treatment modalities
| BC subtype | HR( +)/HER2( − ) | HR( +)/HER2( +) | HR( − )/HER2( +) | HR( − )/HER2( − ) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BM treatment modality | # of Cases | OS | 95% CI | # of Cases | OS | 95% CI | # of Cases | OS | 95% CI | # of Cases | OS | 95% CI |
| No treatment | 1155/1615 | 14.88 | 13.17, 17.02 | 323/477 | 17.74 | 14.09, 22.34 | 237/329 | 11.56 | 7.85, 16.20 | 528/597 | 4.5 | 3.81, 5.03 |
| WBRT | 613/767 | 13.08 | 10.87, 14.39 | 240/331 | 18.83 | 14.23, 22.77 | 208/278 | 15.74 | 12.58, 18.43 | 452/498 | 6.08 | 5.36, 6.87 |
| SRS | 174/257 | 18.53 | 13.86, 22.77 | 48/97 | 39.79 | 28.75, | 51/84 | 16.82 | 10.45, 30.65 | 107/134 | 8.5 | 5.49, 12.35 |
| Surgery | 109/159 | 25.43 | 19.35, 30.72 | 21/39 | 35.98 | 14.36, 53.26 | 25/34 | 10.02 | 4.80, 19.55 | 41/51 | 6.7 | 4.27, 11.37 |
| Surgery + SRS | 52/87 | 28.12 | 19.84, 44.09 | 17/33 | 42.25 | 12.98, | 18/25 | 24.08 | 5.30, 59.17 | 43/53 | 7.46 | 4.44, 16.16 |
| Surgery + WBRT | 29/51 | 33.35 | 24.48, 40.87 | 6/21 | 29.11, | 8/17 | 48.85 | 10.41, | 23/34 | 15.8 | 6.31, 21.98 | |
| Total | 2132/2936 | 655/998 | 547/767 | 1194/1367 | ||||||||
| Log-rank test p-value | < .0001 | < .0001 | 0.0209 | < 0.0001 | ||||||||
| BC treatment modality | ||||||||||||
| No treatment | 463/565 | 2.69 | 2.43, 3.32 | 143/174 | 2.56 | 1.94, 3.02 | 130/152 | 1.77 | 1.45, 2.20 | 441/481 | 2.07 | 1.91, 2.30 |
| Immunotherapy (I) | 4/6 | 18.34 | 1.87, | 19/21 | 4.17 | 2.14, 14.75 | 26/32 | 3.94 | 2.90, 6.05 | 3/6 | 1.45, | |
| Chemotherapy (C) | 340/433 | 12.48 | 10.87, 14.88 | 110/137 | 18.83 | 11.53,23.49 | 205/254 | 15.51 | 12.16, 17.77 | 683/792 | 8.51 | 7.66, 9.23 |
| Hormonal therapy (H) | 746/957 | 15.38 | 13.54,18.20 | 63/70 | 5.6 | 3.22, 9.03 | 5/6 | 0.81 | 0.39, | 11/12 | 3.33 | 0.90, 16.46 |
| I + H | 46/73 | 31.54 | 24.51, 35.38 | 44/65 | 18 | 10.15, 23.36 | 3/4 | 7.36 | 1.35, | – | – | |
| C + H | 481/785 | 26.91 | 25.36, 29.14 | 92/134 | 31.57 | 20.96, 40.31 | 13/13 | 14.16 | 6.01, 24.90 | 17/22 | 10.68 | 6.77, 27.24 |
| C + I | 20/31 | 14.42 | 8.90, 27.07 | 104/209 | 36.37 | 27.50, 51.52 | 156/291 | 30.65 | 22.97, 35.45 | 39/53 | 11.7 | 9.46, 16.72 |
| C + H + I | 31/83 | 55.13 | 35.58, | 77/184 | 42.35 | 36.04, 55.36 | 14-Sep | 31.34 | 7.82, | – | – | |
| Total | 2131/2933 | 652/994 | 547/766 | 1194/1366 | ||||||||
| Log-rank test p-value | < .0001 | < .0001 | < .0001 | < .0001 | ||||||||
| Treatment combination | ||||||||||||
| Neither BM nor BC | 321/398 | 2.56 | 2.10, 3.32 | 85/106 | 2.27 | 1.74, 2.70 | 77/90 | 1.51 | 1.15, 2.0 | 232/248 | 1.87 | 1.58, 2.07 |
| Only BM | 143/170 | 3.25 | 2.50, 4.57 | 61/72 | 3.15 | 1.87, 5.26 | 53/63 | 2.07 | 1.64, 3.48 | 209/234 | 2.3 | 2.07, 2.63 |
| Only BC | 834/1217 | 22.24 | 18.96, 24.77 | 238/371 | 24.67 | 21.19, 28.68 | 160/239 | 19.02 | 14.88, 23.16 | 296/349 | 8.57 | 7.33, 9.89 |
| BM + BC | 834/1151 | 19.02 | 17.08, 20.70 | 271/449 | 28.94 | 24.77, 35.29 | 257/375 | 19.42 | 16.95, 23.36 | 457/536 | 8.84 | 7.85, 9.79 |
| Total | 2132/2936 | 655/998 | 547/767 | 1194/1367 | ||||||||
| Log-rank test p-value | < .0001 | < .0001 | < .0001 | < .0001 | ||||||||