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. 2024 Jun 26;17(6):e13858. doi: 10.1111/cts.13858

FIGURE 2.

FIGURE 2

NF1 +/ex42del miniswine exhibit inconsistent GFAP+ astrocyte expression in the prefrontal lobe, anterior cingulate, and hippocampus. (a) Representative images of GFAP+ astrocytes in the prefrontal tracts of 14‐month‐old wild‐type and NF1 +/ex42del miniswine. (b) GFAP+ analysis of prefrontal tracts indicates significant increases in female NF1 +/ex42del miniswine at 18–24 months of age. (c) Representative images of GFAP+ astrocytes in the anterior cingulate of 14‐month‐old animals. (d) GFAP+ analysis of the anterior cingulate indicates no significant differences at either timepoint. (e) Representative images of GFAP+ astrocytes in the CA1 region of the hippocampus in 14‐month‐old animals. (f) GFAP+ analysis of hippocampus CA1 indicates an increase in astrocyte expression in 14‐month‐old male NF1 +/ex42del miniswine. (g) Representative images of GFAP+ astrocytes in the dentate gyrus of the hippocampus in 14‐month‐old animals. (h) GFAP+ analysis of the dentate gyrus indicates a decrease in male NF1 +/ex42del miniswine at 18 months of age. Unpaired t‐tests. n = 3‐4/group, *p < 0.05, **p < 0.01. Mean ± SEM. Scale bar = 200 μm.