FIGURE 6.

Simple T‐maze indicates delayed and sustained memory and learning deficits in male NF1 ^+/ex42del miniswine with cNFs. (a) T‐maze results for acquisition day 1, indicating no significant differences between wild‐type and NF1 ^+/ex42del miniswine at any age group. (b) T‐maze results for acquisition day 2, indicating learning delays in 18‐month‐old male NF1 ^+/ex42del miniswine with cNFs. (c) T‐maze results for reversal day 1, indicating learning delays between wild‐type and male NF1 ^+/ex42del miniswine with cNFs at 12 and 18 months of age. (d) T‐maze results for reversal day 2, indicating continued learning delays in 12‐ and 18‐month‐old male NF1 ^+/ex42del miniswine with cNFs. Mixed model ANOVA, Tukey post hoc. n = 3–9/group, *p < 0.05, **p < 0.01, ****p < 0.0001. Mean ± SEM.