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. 2024 Jun 26;9:120. doi: 10.1038/s41541-024-00907-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Reciprocal gH/gL endpoint binding titers elicited by LION/repRNA encoding the soluble gH/gL ectodomain measured by ELISA as indicated. Titers elicited by the 10 μg prime-boost regimen with full-length membrane-anchored gH/gL from Fig. 2 are shown for comparison. The sera from (a) was evaluated in neutralization assays carried out in epithelial (b), or B cells (c). Each dot represents the average of three technical replicates for an individual mouse at each timepoint (n = 8 for full-length gH/gL and n = 5 for gH/gL ectodomain) and the lines connect the means. The arrows indicate the time of immunization. Asterisks denote a statistically significant difference between the two groups at a given time point determined using a Mann-Whitney test where * indicates p ≤ 0.05 and ** indicates p ≤ 0.01. d–j Pooled immune sera from mice vaccinated with LION/repRNA encoding full-length and gH/gL ectodomain were evaluated for their ability to compete for binding to EBV gH/gL with the indicated mAbs by competitive ELISA. Each dot represents a technical replicate with a line connecting the mean.