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. 2024 Jun 26;9:120. doi: 10.1038/s41541-024-00907-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Reciprocal endpoint gH/gL binding titers from mice immunized with LION/repRNA encoding gH/gL 4-mer, gH/gL 7-mer and gH/gL 60-mer were measured by ELISA. Titers from two immunizations with 10 μg full-length gH/gL (from Fig. 2) are included for comparison as indicated. EBV neutralizing titers in the serum from the mice in (a) were measured in epithelial (b) and B cell (c) infection assays. Each dot represents the average of three technical replicates for an individual mouse at each timepoint (n = 5 per group in multimer construct vaccinations, n = 8 for full-length gH/gL) and the lines connect the means. The arrows indicate the time of immunization. See Table S2 for statistical comparisons.