Figure 3.

Proposed field change phenomenon. (A) Exposure of normal tissue to external stimuli. (B, C) Basal cell layer undergo genetic and transcriptomic modifications when exposed to external stimuli. (B) Different shades of blue in the nuclei of basal cells represent genomic divergence. (C) Varying shades of brown in the cytoplasm of basal cells represent common transcriptomic profile (e.g. Hedgehog pathway). (D) Formation of synchronous tumors harboring common signaling pathway but divergent genomic make-up.