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. 2024 Jun 13;15:1414737. doi: 10.3389/fimmu.2024.1414737

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Copyright © 2024 Roehnisch, Martos-Contreras, Manoochehri, Nogueira, Bremm, Dörrie, Christoph, Kunz and Schönharting

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Treatment process and follow-up of metastatic pancreatic cancer patient through treatment periods. The patient received different treatments at different times. BITAP immunization was applied along with standard of care chemotherapy (A). Immunogenicity testing of manufactured peptides by IVS- (B) and Ex-Vivo (C) IFN-γ ELISPOT assays. CA19-9 marker levels of the patient throughout the treatment (D). Immuno-monitoring of the patient during the treatment (E) MRI scan was performed before and approximately three and six months after the start of BITAP immunization (F).