Table 3.
Change in the levels of significantly altered metabolites (n = 25) in MS group (n = 90) compared to control group (n = 30).
| Metabolites | p-valuea | Fold change (MS vs Ctrl)b |
|---|---|---|
| Lysine | 3.11E-19 **** | ↓ (0.48) |
| myo-Inositol | 6.13E-18 **** | ↓ (0.36) |
| Glutamate | 1.56E-16 **** | ↓ (0.57) |
| Threonine | 7.64E-16 **** | ↓ (0.38) |
| Glycine | 9.51E-15 **** | ↓ (0.45) |
| Tyrosine | 3.33E-12 **** | ↓ (0.61) |
| Choline | 5.18E-12 **** | ↓ (0.50) |
| O-phosphocholine | 1.79E-09 **** | ↓ (0.54) |
| Serine | 7.47E-08 **** | ↓ (0.71) |
| Tryptophan | 4.39E-07 **** | ↑ (3.34) |
| Phenylalanine | 9.54E-07 **** | ↓ (0.64) |
| Cysteine | 1.10E-06 **** | ↓ (0.65) |
| Succinate | 2.50E-06 **** | ↑ (1.58) |
| Creatine | 1.64E-05 **** | ↓ (0.46) |
| ATP | 1.11E-04 *** | ↑ (1.98) |
| Creatine phosphate | 1.39E-04 *** | ↓ (0.49) |
| NAD + | 1.77E-04 *** | ↑ (1.90) |
| O-phosphoethanolamine | 4.79E-04 *** | ↓ (0.70) |
| Formate | 5.65E-04 *** | ↑ (2.47) |
| Inosine | 1.24E-03 ** | ↑ (1.61) |
| sn-glycero-3-phosphocholine | 1.67E-03 ** | ↓ (0.77) |
| Histidine | 2.90E-03 ** | ↑ (1.90) |
| Glutathione | 3.29E-03 ** | ↑ (1.47) |
| Pantothenate | 5.54E-03 ** | ↑ (1.37) |
| Fumarate | 1.76E-02 * | ↓ (0.57) |
ap-values obtained by t-test, *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.
bMetabolites with ↑ indicates increased levels in serum of MS group while ↓ indicates decreased levels in serum of MS group compared to control group.