Table 3.
Association between HbA1c and glycemic control (independently) and prevalent MCI (average 7 years from visit 1; laboratory measurement of HbA1c) in SOL-INCA
| MCI, OR [95% CI] | |||||
|---|---|---|---|---|---|
| M1 | M2 | M3 | M4 | M5 | |
| HbA1c (%) | 1.23*** [1.15; 1.32] | 1.22*** [1.14; 1.31] | 1.21*** [1.13; 1.30] | 1.20*** [1.12; 1.29] | 1.20*** [1.11; 1.29] |
| Glycemic control (HbA1c) | |||||
| No diabetes | Ref. | Ref. | Ref. | Ref. | Ref. |
| Prediabetes | 0.96 [0.69; 1.34] | 0.93 [0.67; 1.29] | 0.93 [0.67; 1.28] | 0.93 [0.67; 1.28] | 0.90 [0.64; 1.25] |
| Controlled | 1.10 [0.69; 1.77] | 1.05 [0.66; 1.69] | 1.04 [0.65; 1.67] | 1.02 [0.64; 1.65] | 0.99 [0.61; 1.60] |
| Poorly controlled | 2.37*** [1.72; 3.26] | 2.22*** [1.62; 3.05] | 2.14*** [1.56; 2.95] | 2.06*** [1.50; 2.84] | 1.99*** [1.44; 2.75] |
| Unweighted n | 5,747 | 5,747 | 5,747 | 5,747 | 5,747 |
M1 adjusts for age, sex; M2 adds education; M3 adds additional adjustment for Hispanic/Latino heritage and study site (center); M4 adds depressive symptoms; M5 adds diet, physical activity, BMI, alcohol consumption, and smoking. For the categorical measure, the no diabetes group is the reference (Ref.) in the models used to calculate the marginal estimates.
***
P < 0.001.