Table 3.
Effect of different bovine alphaherpesvirus (BoAHV) vaccine formulations on the total antibodies produced in the guinea pig and bovine experiments according to ELISA.
| Vaccine Formulations |
Guinea Pig Experiment | Bovine Experiment |
|---|---|---|
| Effect of vaccine formulation | 0.0005 | 0.0005 |
| Effect of time | 0.0162 | <0.0001 |
| Interaction of vaccine × time | 0.0050 | <0.0001 |
| Vaccine A | 7.71 ± 7.71 | Reproved |
| Vaccine B | 533.33 ± 282.21 | 426.66 ± 164.86 |
| Vaccine C | 320.00 ± 96.48 | Reproved |
| Vaccine D | 693.33 ± 329.16 | 780.95 ± 229.19 |
| Vaccine E | 40.00 ± 40.00 | Reproved |
| Vaccine F | 70.00 ± 53.51 | Reproved |
| Vaccine G | 11.42 ± 5.01 | Reproved |
| Vaccine H | No-tested | 657.77 ± 165.01 |
| Non-vaccinated Guinea pig and bovine model |
0.00 ± 0.00 | |
Guinea pig experiment was conducted to screen vaccines for the second experiment. Reproved—vaccines not selected for the second bovine experiment because of the low antibody titers developed after vaccination; non-tested—modified live vaccine was not tested in guinea pig models because of the low adaptability of bovine viral diarrhea virus (BVDV) in this animal species. The effects of the vaccine group, time, and interaction between the group and time were determined using a MIXED models procedure.