Figure 2.

Protective efficacy of the glycoprotein-targeting antiserum against MACV strain Chicava challenge in guinea pigs. (A) Guinea pigs (n = 6/group) were treated with antisera (anti-MACV) or control antisera at the indicated time points. The guinea pigs were infected by the i.p. route with 1000 pfu MACV strain Chicava. The animals were injected s.c. with 15,000 TU/kg (based on a 400 g guinea pig) of rabbit anti-MACV Carvallo glycoprotein or control antiserum diluted in PBS. TU determined antibody was based on PRNT80 valuates against the strain Carvallo. A second dose of antiserum was administered five days later. Survival was monitored for 30 days post-infection. The survival and percent group weight loss change was plotted. The weights were calculated based on day 0 starting weight. (B) The weight changes of individual animals treated with anti-MACV GPc antiserum (left) or control antiserum (right) were plotted. (C) Temperatures were monitored daily by IPPT-300 implants. The mean group temperatures were plotted. The normal guinea pig temperature range is shaded in grey.