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SPIKENET structure and binding affinity to the ACE2 binding domain of the SARS-CoV-2 spike glycoprotein. Structure of SPIKENET, a 15-amino-acid synthetic peptide targeted to the ACE2 binding domain of the SARS-CoV-2 spike glycoprotein (top image). The computational protein docking approach shows particular SPIKENET binding affinity to the ACE2 and CEACAM1 binding domains of the SARS-CoV-2 and MHV-1 spike glycoproteins (S1), respectively (bottom images) [13].
