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Elevated edema was observed in MHV-1-infected brain, lung, liver, kidney, and heart, as compared to control, which was similar to patients with COVID-19. Treatment of MHV-1-infected mice with SPK (5 mg/kg; 3 injections from 2 to 6 days) showed edema levels comparable to control levels on day 7. ANOVA, n = 5 for control, n = 16 for virus alone, and n = 7 for MHV1 + SPK group. * = p < 0.05 versus control; † = p < 0.05 verses MHV-1 infected mice, Error bars represent mean ± SEM [13].
