Figure 4. Contrasts in Associated Risk by Dosage Change Across Recurrent Copy Number Variant (rCNV) Loci.

Hazard ratios (HRs) with error bars indicating SE for deletions and duplications are plotted on the x-axis and y-axis, respectively, for attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and schizophrenia spectrum disorder (SSD). The 16 loci with available HR estimates for both deletions and duplications for at least 1 diagnosis are indicated by different colors corresponding to previous figures. The dashed line indicates risk parity. We found no evidence of a locus-by-dosage interaction increasing prediction of case status in an overall test across all loci and diagnoses between a generalized estimating equation model with the interaction term and a nested model without the interaction term (likelihood ratio test, P = .16).