Table 3.
Compounds disturbing cellular lipidome homeostasis as potential candidate antivirals.
Virus | Compounds | References |
---|---|---|
Rotavirus | TOFA; [isoproterenol + IBMX] | [2,17] |
Hepatitis C virus | Cyclophilin inhibitors blocking viral RNA replication | [42] |
Enterovirus | CAY10499 (hormone-dependent lipase inhibitor) and atglistatin (adipose triglyceride lipase inhibitor), both reducing viral replication | [36] |
SARS-CoV-2 | drugs reducing cholesterol synthesis and esterification, LD formation, and ceramide biosynthesis | [7,9,43] |
HIV-1 | neutral sphingomyelinase 2 inhibitor (PDDC) blocking maturation and full infectivity of HIV-1 particles | [38,39] |