Table 3.
Comparison of sFlt-1, PlGF and their ratio as well as parameters of maternal hemodynamic function between patients with SARS-CoV-2 infection during pregnancy and healthy controls. Data presented as median and IQR or numbers (%).
| COVID-19 during Pregnancy (n = 23) |
Healthy Controls (n = 46) |
p-Value | |
|---|---|---|---|
| sFlt-1/PlGF ratio, median (IQR) | 4.3 (2.6–5.8) | 3.6 (1.8–6.3) | 0.795 |
| sFlt-1, pg/mL (IQR) | 1543.5 (1076.5–2022.5) | 1422.5 (1133.0–1756.0) | 0.795 |
| PlGF, pg/mL (IQR) | 350.5 (234.0–518.5) | 422.5 (242.0–627.0) | 0.437 |
| USCOM-1A® Monitor | |||
| Body Surface Area, m2 (IQR) | 1.9 (1.8–2.2) | 1.8 (1.8–1.9) | 0.551 |
| Outflow Tract Diameter (OTD), (IQR) | 1.9 (1.9–1.9) | 1.9 (1.9–2.0) | 0.670 |
| Mean Arterial Pressure, mmHg (IQR) | 83.0 (79.0–95.0) | 82.5 (79.0–87.5) | 0.544 |
| Velocity Peak, median (IQR) | 1.5 (1.4–1.6) | 1.5 (1.4–1.6) | 0.648 |
| Heart Rate, beats/min (IQR) | 80.0 (72.0–87.0) | 75.0 (69.0–82.0) | 0.443 |
| Stroke Volume (SV), mL (IQR) | 92.0 (81.0–103.0) | 87.0 (73.0–96.0) | 0.268 |
| Stroke Volume Index (SVI), mL/m2 (IQR) | 46.0 (40.0–54.0) | 48.0 (39.0–53.5) | 0.669 |
| Cardiac Output (CO), L/min median (IQR) | 7.1 (5.9–8.2) | 6.7 (5.8–7.2) | 0.348 |
| Cardiac Index, L/min/m2 median (IQR) | 3.6 (3.2–4.1) | 3.6 (3.1–4.0) | 0.797 |
| Systemic Vascular resistance (SVR), d.s.cm−5 (IQR) | 998.0 (890.0–1087.0) | 1030.0 (921.0–1125.5) | 0.670 |
| Systemic Vascular Resistance Index (SVRI), d.s.cm−5 m2 (IQR) | 1861.0 (1665.0–2082.0) | 1896.0 (1634.0–2241.0) | 0.932 |
| Stroke Volume Variability, median (IQR) | 14.0 (12.0–20.0) | 11.0 (7.3–20.5) | 0.074 |
| Inotropy Index, W/m2 (IQR) | 1.6 (1.5–1.8) | 1.8 (1.5–1.8) | 0.670 |
| PE/KE Ratio, median (IQR) | 23.0 (17.0–28.0) | 22.0 (20.0–26.0) | 0.932 |
| Stroke work, mmHg/mL (IQR) | 1060.0 (901.0–1161.0) | 926.5 (812.0–1072.0) | 0.033 |
| Cardiac Power, W (IQR) | 1.3 (1.1–1.7) | 1.2 (1.0–1.3) | 0.106 |
| Arteriograph | |||
| Pulse Pressure, mmHg (IQR) | 47.0 (42.0–54.0) | 47.0 (42.0–53.0) | 0.826 |
| Brachial Augmentation index, % (IQR) | −52.9 (−60.9–−45.6) | −61.1 (−67.6–−44.7) | 0.924 |
| Central systolic Blood Pressure (SBPao), mmHg (IQR) | 100.0 (94.0–108.0) | 100.0 (92.0–111.0) | 0.942 |
| Central aortic Pulse Pressure (Ppao), mmHg (IQR) | 35.2 (30.4–36.0) | 34.3 (31.1–39.8) | 0.942 |
| Augmentation index Aortic, % (IQR) | 10.9 (6.8–14.5) | 6.7 (3.5–15.0) | 0.942 |
| Aortic Pulse Wave Velocity (PWVao), m/s (IQR) | 7.3 (6.5–8.4) | 7.1 (6.4–7.9) | 0.504 |