Table 1.

BoNT products commercially available or in development in selected regions worldwide.

Trade Name(s)	Nonproprietary USAN Name	Manufacturer	Serotype	Complex Size or NT Only	Formulation	Selected Regions Approved *
Commercially available
BOTOX®, BOTOX® Cosmetic, Vistabel®, Vistabex® [4,6]	OnabotulinumtoxinA	Allergan/AbbVie	A	~900 kDa	In 100 U vial 900 μg sodium chloride 500 μg human serum albumin Finishing: vacuum dried	USA, Canada, EU, China, Japan, South Korea, Brazil
Dysport®, Azzalure® [7,8]	AbobotulinumtoxinA	Ipsen	A	~400 kDa **	In 500 U vial 2.5 mg lactose 125 μg human serum albumin Finishing: lyophilized	USA, Canada, EU, China, South Korea, Brazil
Xeomin®, Boucouture® [9]	IncobotulinumtoxinA	Merz	A	~150 kDa	In 100 U vial 4.7 mg sucrose 1 mg human serum albumin Finishing: Lyophilized	USA, Canada, EU, Japan, South Korea, Brazil
Nabota®, Jeuveau®, Nuceiva® [10,11]	PrabotulinumtoxinA	Evolus/Daewoong	A	~900 kDa	In 100 U vial 900 μg sodium chloride 500 μg human serum albumin Finishing: vacuum dried	USA, Canada, EU, South Korea, Brazil
Daxxify™ [12]	DaxibotulinumtoxinA-lanm	Revance	A	~150 kDa	In 100 U vial 0.14 mg L-histidine 0.65 mg L-histidine-HCl monohydrate 0.1 mg polysorbate 20 11.7 µg RTP004 peptide 36 mg trehalose dihydrate Finishing: lyophilized	USA
Myobloc® [13,14]	RimabotulinumtoxinB	Solstice	B	~700 kDa	In 5000 U vial 5.8 mg sodium chloride 470 μg human serum albumin 2.7 mg sodium succinate Finishing: liquid	USA, Canada
AlluzienceTM (EU) [8,15]	AbobotulinumtoxinA solution for injection	Ipsen	A	~400 kDa	1.55 mg L-histidine 4.0 mg sucrose 8.76 mg sodium chloride 0.10 mg polysorbate-80 0.10 mg, hydrochloric acid to Finishing: liquid (in water for injection	EU
Neuronox®/Meditoxin®	Unassigned	Medytox	A	NR	Information from the manufacturer could not be identified.	South Korea, Brazil
Innotox®	Unassigned	Medytox	A	NR	Information from the manufacturer could not be identified.	South Korea (approved in 2018; product not available at the time of manuscript submission)
Botulax® (Korea) [16], Letybo® [17] EU: 50 U vial only	LetibotulinumtoxinA	Hugel	A	NR	In 100 U vial 0.9 mg sodium chloride 0.5 mg HSA Finishing: lyophilized	Canada, EU, China, South Korea, USA
Relatox® [18]	None established	Microgen	A	NR	In 100 U vial: 6 mg gelatin 12 mg maltose Finishing: lyophilized	Russia
Hutox® (Liztox®) [19]	None established	Huons	A	900 kDa	NR	South Korea
Lantox® (Hengli®, Prosigne®, Lantox®, Lazox® Redux®, Liftox®) [20,21,22]	None established	Lanzhou	A	900 kDa	In 100 U vial: 5.0 mg gelatin 25 mg dextran 25 mg sucrose Finishing: lyophilized	EU, China, South Korea, Brazil
In Development
NR [23,24]	RelabotulinumtoxinA	Galderma	A	~150 kDa	Saline phosphate buffer (salt amounts not reported) Finishing: liquid
NR [25,26]	TrenibotulinumtoxinE	Allergan Aesthetics, an AbbVie company	E	NR	NR

HCl = hydrochloric acid; HSA = human serum albumin; kDa = kilodalton; mg = milligram; NR = not reported; NT = neurotoxin; U = unit; USAN = United States Adopted Name; μg = microgram. * Approved for one or more indications in the listed countries/regions as of August 2023 based on a search of publicly available information and, for Korean approvals, Wee and Park, 2022 [27]. Specificity of indications and trade names vary from country to country based on local regulatory approvals. See local prescribing information for current indication specifics, including any limitations of use, warnings and precautions, dosage and administration, and adverse reactions. ** The molecular size of the abobotulinumtoxinA neurotoxin complex has been reported to be heterogeneous [28].