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. 2024 Jun 9;16(6):935. doi: 10.3390/v16060935

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Validating the neutralization profile of mAbs PGT126 and PG9 against different viruses. (A) Neutralization sensitivities of IIIB and BaL viruses grown in the PM1 and H9 CD4⁺ T cell lines using PG9 (blue) and PGT126 (red) mAbs. (B) Neutralization of HIV BaL produced in two different PBMC donors (D1 and D2). (C) Neutralization of virus produced through the transfection of HEK293T cells with the NL4-3-BaL infectious molecular clone. All neutralization tests were performed using the TZM-bl reporter cell assay, with the infection of control samples (in absence of mAbs) set at 100%. Data are representative of two independent experiments tested with triplicate wells.