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Tau in the cortex postsynaptic density (PSD). A, Subcellular fractionation technique to isolate PSD. The red line indicates the synaptosome fraction used to further isolate the PSD. B, C, Western blot analysis of cortex PSD samples showing soluble phosphorylated Tau (AT8) accumulation with age in PS19 and WT females (B) and males (C). Western blots also include total Tau and PSD95, a protein enriched in the PSD.
