Figure 7.

Chronic sleep disruption is a driver of Tau pathology in LC. A, Histology of locus ceruleus sections from PS19 mice under control or following 30 d of CSD treatment. Slices stained with TH to mark the noradrenergic neurons and AT8 to mark the Tau pathology. Example images from female PS19 mice. B, % area positive for AT8 in females, males, or combined. No AT8 signal was detected in WT littermates; therefore, statistical analysis was only conducted comparing control and CSD treatment in PS19 animals. CSD drove a significant increase in AT8 % area compared with control treatment in PS19 females or combined sexes. PS19 males showed a trend to increase. *p < 0.05 unpaired two-tailed Student's t test between the control and treatment groups for PS19 genotype. Error bars indicate mean ± SEM.