Chronic sleep disruption leads to changes in hippocampal synaptic protein expression in PS19 females but not males. A, B, Western blot analysis of hippocampal synaptic receptor expression in 6-month-old PS19 females (A) and males (B). C, Quantification of hippocampal protein expression in PS19 females. N = 5 control; 5 CSD. D, Quantification of hippocampal protein expression in PS19 males. N = 4 control; 6 CSD. All antibodies normalized to loading control and then normalized to the control group. Unpaired two-tailed Student's t test between the control and treatment groups for each genotype. *p < 0.05, **p < 0.01, ***p < 0.001. Error bars indicate mean ± SEM. E, F, Western blot analysis of cortical synaptic protein expression in 6-month-old PS19 females (E) and males (F). G, Quantification of cortical synaptic protein expression in PS19 females. N = 5 control; 5 CSD. H, Quantification of cortical synaptic protein expression in PS19 males. N = 4 control; 6 CSD. All antibodies normalized to loading control and then normalized to the control group. Unpaired two-tailed Student's t test between the control and treatment group for each genotype. Error bars indicate mean ± SEM.