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. 2024 Jun 17;14(9):3739–3759. doi: 10.7150/thno.97412

Figure 4.

Figure 4

Immunomodulatory properties of the 2Mg@PEG-PLGA hydrogel. (A) Immunofluorescence images of iNOS, Arg-1 and DAPI staining of macrophages in the different groups. FCM results of (B) M1 (CD86+) and (C) M2 (CD206+) macrophages. (D-G) Secretion levels of TNF-α, IL-1β, TGF-β and IL-10 in macrophage suspensions. (H) Representative Western blot images of p-IκBα, IκBα, p-NF-κB, NF-κB and β-actin in the indicated groups. Quantitative analyses of the (I) p-IκBα/IκBα and (J) p-NF-κB/NF-κB ratios. (K) Schematic illustration of the immunomodulatory mechanism of the 2Mg@PEG-PLGA gel. The data are expressed as the mean ± SD (n=3). *p < 0.05, **p < 0.01 and ***p < 0.001.