Table 3.
Bispecific or trispecific agents in preclinical development for Trop2-expressing tumors
| Name | Institute/ Company | Type | Target | Reference/ Patent |
|---|---|---|---|---|
| (E1)-3s | Immunomedics | Bispecific antibody | Trop2, CD3 | 69, 70 |
| F7AK3 | Huazhong University of Science and Technology Tongji Medical College | Bispecific antibody | Trop2, CD3 | 71 |
| Trop2/CD3 bispecific antibody | Arbele Corp | Bispecific antibody | Trop2, CD3 | 73 |
| Sunshine Guojian anti-Trop2/CD3 bispecific antibody | Sunshine Guojian Pharmaceutical (Shanghai) | Bispecific antibody | Trop2, CD3 | 72 |
| EX108 | Excelmab | Bispecific antibody | Trop2, CD3 | WO2019184549A1 |
| Janux patent anti-Trop2/CD3 bispecific antibody | Janux Therapeutics | Bispecific antibody | Trop2, CD3 | WO2023164513 |
| BiOneCure patent anti-Trop2/HER2 bispecific antibody | BiOneCure Therapeutics | Bispecific antibody | Trop2, HER2 | WO2022159984 |
| Zeda Bio patent anti-Trop2/PD-L1 bispecific antibody | Zeda Biopharmaceuticals | Bispecific antibody | Trop2, PD-L1 | WO2023098770 |
| Xencor patent anti-Trop2/CD28 bispecific antibody | Xencor | Bispecific antibody | Trop2, CD28 | WO2023164640 |
| TF12 | Radboud University Medical Center | Bispecific antibody | Trop2, HSG | 90 |
| Trop2 ProTriTAC | Harpoon Therapeutics | Trispecific antibody | Trop2, CD3, HSA | 74 |
| Boehringer patent anti-Trop2/CD3/CDH-17 trispecific antibody | Boehringer Ingelheim | Trispecific antibody | Trop2, CD3, CDH-17 | WO2022263507 |
| YH012 | Beijing Biocytogen | Bispecific ADC | Trop2, HER2 | 76 |
| BCG033 | Beijing Biocytogen | Bispecific ADC | Trop2, PTK7 | 79 |
| BCG011 | Beijing Biocytogen | Bispecific ADC | Trop2, EGFR | WO2023046061A1 |
| DM001 | Xadcera Biopharmaceutical | Bispecific ADC | Trop2, EGFR | 75 |
| JSKN016 | Alphamab Oncology | Bispecific ADC | Trop2, HER3 | Not applicable |
| HuNbTROP2-HSA-MMAE | Shanghai Novamab Biopharmaceuticals | Bispecific ADC | Trop2, HSA | 80 |
HER2, human epidermal growth factor receptor 2; PD-L1, programmed death-ligand 1; HSG, histamine-succinyl-glycine; CDH-17, cadherin-17; PTK7, protein tyrosine kinase-7; EGFR, epidermal growth factor receptor; HER3, human epidermal growth factor receptor 3;HSA human serum albumin.